ANDY SPEZZATTI//SIMULATION & AGENT EVALUATION

Andy Spezzatti — I work on how to know whether AI agents actually work.

At Zapier I build the evaluation infrastructure for agentic automation: simulated worlds that agents act in, end-to-end scenarios grounded in real outcomes, and the tooling that turns those measurements into release decisions.

I've been circling the same question for a while. At Genentech I built simulation engines so a portfolio of three hundred clinical trials could be planned before reality arrived. At Taltrics, which I co-founded, we shipped multi-agent systems to enterprises and post-trained them to stop hallucinating tool calls. The instrument keeps changing; the question — how do you trust a system before it meets the world? — hasn't. Along the way I published on trustworthy AI in healthcare.

Fig. 00 // Thesis InstrumentSimulating Systems Before Reality Arrives
ΔS = Sₜ − S₀ · Grounded World Outcome
World Fixture Complexity (fields per CRM record)312 fields
Local Interface Check5/5 isolated pass
Grounded World Outcome8/10 pass (verified ΔS)
Execution Latency75s (vs 210s raw)
01Writing
Flagship essays with interactive models & working field notes.
ESSAY 01·11 MIN READJun 2026
Eval-Driven Development

Agents move decisions out of control flow and into the model. That part of the specification can only be recovered by watching the system act, which makes the eval the place where it gets written.

§ Evals discover the contract · § The world can make the spec false · § Outcomes cross ownership boundaries◆ Interactive Model
ESSAY 02·8 MIN READDec 2022
Priors for a portfolio

A model's job is to be honest about what it doesn't know, in a form a decision can use. Three years of simulating clinical trials taught me what that means.

§ Two patients at a site · § The decision is the output · § Why simulate◆ Interactive Model
Field Notes Logbook3 entries
  1. Which branch would you bet on
    A leaderboard reports scores. A decision needs a preference and an uncertainty, and frontier scenarios are exactly where you have neither by default.
    Aug 2026
  2. Known-bad candidates
    An eval that has never been shown a wrong answer has not been shown to measure anything.
    May 2026
  3. Five of five is not a statistic◆ Interactive
    What repeated eval runs can tell you, what they cannot, and why the two get confused.
    Apr 2026
02Systems
Production architectures and what happened when they met the world.
  1. Eval infrastructure for agentic automation
    Zapier — simulated worlds and release gates for an agent platform used by 1.5M+ people.
    2025 –
  2. Scoping and pricing a deal on the call
    Taltrics — agents that take an RFP to a priced proposal in minutes, post-trained so the number is right.
    2022 – 25
  3. Simulating a clinical-trial portfolio
    Genentech / Roche — a discrete-event engine behind planning for 300+ trials in 70 countries.
    2019 – 22
03Questions
Active open problems I am working on right now.
  1. How do you attribute an agent's failure to the step that caused it, rather than grading only the final state?
  2. What does a simulated world need to contain for an eval result to transfer to production behavior?
  3. Which properties of a benchmark predict that improvements on it will show up for real users?
04Papers
Selected peer-reviewed publications.